The Methylation Maze: Why Knowing Your Genes Matters for Choosing Supplements
Some of us have heard of the methylation pathway or the MTHFR gene more affectionally know as the motherf*%$er gene.
Every one has likely heard of folate, a vital B vitamin.
You, like most have done your research to learn about this gene the importance of supplementing with methylfolate (5-MTHF) thinking you have solved why you feel so bad. You start taking 5-MTHF excited about the new world that is about to open before you only to end up feeling worse.
When Your Body Needs Methylfolate
Methylfolate is the active, usable form of folate. The MTHFR gene mutation, acts like a traffic jam in your body’s methylation cycle, making it difficult to convert the standard folic acid found in green leafy vegetables and most supplements into this active form. This sluggish process can lead to a host of issues, including
low energy,
mood imbalances
poor detoxification.
For those with this mutation, supplementing directly with methylfolate is like providing the engine with the right fuel. It bypasses the genetic roadblock and helps restore the body’s natural balance, fueling critical processes that rely on this vital vitamin.
When Too Much of a Good Thing Is Bad
But here’s the catch: methylfolate is not a one-size-fits-all solution. For people who don’t have the MTHFR mutation or who do but also have a COMT mutation taking methylfolate can be a really bad idea. Your methylation cycle can go into overdrive, leading to a state called overmethylation.
This hyperactive state can cause an overproduction of neurotransmitters like dopamine and norepinephrine, which your body struggles to clear. The result is often a feeling of being:
anxiety
insomnia
agitation
This is why people can sometimes feel worse when taking methylfolate when they expected to feel better.
The Complex Case of the Double Mutation
If you have both an MTHFR mutation and a COMT mutation. The MTHFR gene makes you an undermethylator (slow production), while the COMT gene makes you slow at clearing out neurotransmitters, causing a backup that can mimic overmethylation. This can create a confusing mix of symptoms, such as
fatigue
depression
anxiety
restlessness.
In this case, the solution is a careful balancing act. You would start with a very low dose of methylfolate to support your sluggish system while also using cofactors like magnesium and B vitamins to help your COMT enzyme work more efficiently.
Ultimately, your genetic makeup holds the key to your vitamin needs. Instead of guessing, work with a healthcare professional to determine your unique methylation status through genetic and blood tests. It’s the only way to navigate the maze and find the right path to better health.
This is not medical advice consult your heatlhcare professional to discuss if this approach or testing would be applicable for you.
